De-risking & Accelerating Small Molecule Development

At Solvias, we help unlock the full potential of your small molecule drug development with fully integrated analytical and manufacturing solutions. From raw materials to API development, and from CMC analytics to final release testing, we provide a single, trusted partner for your entire drug development journey—ensuring speed, efficiency, and compliance.

Integrated Solutions for Small Molecule Development

By leveraging our expertise in catalysis, synthetic chemistry, and process optimization, we mitigate risks and accelerate drug development timelines.

Analytical CMC & API Development

Solvias provides fully integrated analytical CMC and API development solutions, covering:

Method development & validation tailored for phase-appropriate execution
Analytical characterization for drug substances & drug products
Separation science & elemental analysis (HPLC, GC, ICP-MS, XRF, spectroscopy, etc.)
Physical and solid-state analytics, including polymorphism, crystallization, and stability testing

Catalysis & Ligand Development

Our catalysis team pioneers scalable, cost-effective routes for early-phase API synthesis. With a 700+ derivative ligand portfolio, state-of-the-art automation, and expertise in earth-abundant metal catalysis, we deliver cutting-edge solutions in:

Reaction optimization & high-throughput screening
Scalable process design
Asymmetric hydrogenation & cross-coupling technologies

Chemical & Analytical Development (CHAD)

Our CHAD platform integrates chemical development, solid-state optimization, and GMP manufacturing into a flexible, milestone-driven approach.

Defining robust chemical routes from mg to kg scale
Developing phase-appropriate GMP processes
Parallelized work streams for accelerated timelines
Transparent project management with expert guidance

Expertise in Solid-State Development

Solvias excels in polymorph screening, salt formation, and crystallization process development, ensuring optimal API performance. Our capabilities include:

High-throughput crystallization screening (up to 192 micro-experiments per study)
Comprehensive solid-state characterization (PXRD, DSC, NMR, DVS, microscopy)
Crystallization scale-up from micrograms to 100+ liters

Our integrated crystallization solutions provide a robust, scalable path to regulatory approval, ensuring batch consistency and stability from clinical trials to commercialization.

World-Class GMP Manufacturing & Scale-Up

Integrated kilo lab and GMP manufacturing solutions for small molecule APIs, combining advanced process development, impurity profiling, and regulatory expertise to ensure seamless tech transfer and validated, high-quality clinical and commercial supply.

Multipurpose reactors (10–100 L), -80°C to 250°C
High-pressure chemistry (up to 300 bar)

Chromatographic purification (up to 20 kg scale)

Containment labs & HEPA-filtered environments for high-potency APIs

Partner with global life science innovator to achieve your commercialization goals

Solvias combines cutting-edge science, industry-leading expertise, and fully integrated services to deliver high-quality, phase-appropriate solutions at every stage of small molecule development.

Let’s bring your innovation to its destination—on time and with confidence.